Articaine EP Impurity B HCl CAS 114176-52-2(Free Base)
| CAS No. | 114176-52-2(Free Base) |
| Molecular Formula | C12H18N2O3S |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 306.81 g/mol gives Articaine EP Impurity B HCl distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Articaine EP Impurity B HCl (CAS 114176-52-2(Free Base)) is a certified pharmaceutical impurity reference standard with the molecular formula C12H18N2O3SHCl and a molecular weight of 306.81 g/mol.
Based on its molecular formula C12H18N2O3SHCl, Articaine EP Impurity B HCl contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 306.81 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H18N2O3S HCl |
| Molecular Weight | 306.81 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Articaine Standards
- Articaine EP Impurity B (CAS 114176-52-2)
- Articaine EP Impurity J (CAS 1160919-46-9)
- Articaine Impurity N21 (CAS 13781-65-2)
- Articaine impurity 01 (CAS 161448-93-7)
- Articaine impurity 17 HCl (CAS 161449-05-4)
- Articaine EP Impurity A (CAS 1712677-79-6)
- Articaine EP Impurity A HCl (CAS 1712677-79-6(free base))
- Articaine EP Impurity E (CAS 1796888-45-3)
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